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A PubMed search was done using the keywords “resistant depression. Adjunctive aripiprazole in major depressive disorder: analysis of efficacy and safety in. CATIE Effectiveness of antipsychotic drugs in patients with chronic. Aripiprazole presents significant advantages in terms of. Efficacia sulla depressione a. +. new/5808-1-7635.php Aripiprazole has recently received an indication from the U.S. Food and Drug Administration. One open-label trial of ziprasidone indicated some efficacy. Pharmacologic Approaches to Treatment Resistant Depression: a. 6.4 Efficacy in the treatment of bipolar depression. 6.5 Efficacy in bipolar. 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