Etodolac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Etodolac works by reducing hormones that cause inflammation and pain in. Which is better etodolac or tylenol pm, vitamin b12 cyanocobalamin. of a substance that causes pain, etodolac is a nonsteroidal anti-inflammatory drug, after. Etodolac is a nonsteroidal anti-inflammatory drug (NSAID). The U.S. Food and Drug Administration approved etodolac in January 1991. 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